Create Fertility Logo
Loading ...
 

What is Natural Modified IVF?

Natural Modified IVF, is a form of Natural IVF where the treatment is carried out within your natural menstrual cycle but is modified by introducing additional medication aimed at blocking your spontaneous ovulation and supporting the growth of the naturally selected follicle. This treatment has an improved success rate compared with Natural IVF while retaining many of the benefits.

During treatment, you will be given medication for 3-4 days to keep the follicles growing healthy and to avoid spontaneous ovulation prior to egg collection. Throughout your IVF cycle our doctors use advanced ultrasound technology to monitor the health and quality of your developing follicles as well as your body’s response to treatment. This allows our medical team to tailor treatment to offer you the best possible chance of success while protecting your safety and reducing side effects.

Our IVF treatments require specialist medical expertise and are delivered only by consultants. For the best chance of success, the clinic must be completely committed to this type of approach - and we are the only dedicated Natural and Mild IVF clinic in the UK.

Who is it for?

  • Women with low ovarian or egg reserve
  • Women with low Anti-Müllerian Hormone (AMH) or high Follicle Stimulating Hormone (FSH)
  • Women who have had a poor response to conventional high-stimulation IVF (e.g. produced fewer than three eggs)
  • Women who suffer from severe endometriosis
  • Women who have a history of hormone-dependent cancers
  • Women who've had previous failure of implantation with conventional high-stimulation IVF or want to avoid the risks and side effects of high-stimulation IVF
  • Women who are older but wish to try with their own eggs, rather than with donor eggs

Download our free brochure

 

What are the benefits of Natural Modified IVF?

Lower doses of fertility drugs and shorter treatment times

The conventional high-stimulation IVF approach generally uses drugs to shut the natural menstrual cycle down (‘downregulation’) before restarting it again and uses higher doses of stimulation drugs to mature lots of follicles. Natural Modified IVF does not shut the woman’s natural cycle down but works within it, and the process is focused on collecting the one or more high quality follicles naturally selected by the body.

In conventional high-stimulation IVF drugs are given in the form of daily injections for up to 21-28 days of daily injections before egg collection.  In Natural Modified IVF, medication is given to block spontaneous ovulation and support the naturally selected follicle.  Medication is usually given for just 3-4 days, therefore drastically reducing the length of time taking injections and reducing the overall duration of treatment by weeks.

Reduced side effects and emotional burden

Studies have shown that higher doses of stimulation hormones can have a significant physical and emotional burden on patients.

 

Potential side effects of downregulation, a practice not included in any of our treatments, can include:

  • Menopausal symptoms (such as hot flushes)
  • Strong mood swings (such as feeling down or irritable) 
  • Headaches or migraines
  • Fatigue
  • Potential psychological or emotional burden

 

Potential side effects from high stimulation can include: 

  • Increased risk of thromboembolism
  • Increased risk of developing Ovarian Hyperstimulation Syndrome (OHSS)
  • Possible weight gain
  • Risk of bloating and swelling
  • Potentially high psychological or physiological burden

 

Going through IVF treatment can be a highly emotive and stressful experience. At CREATE Fertility, we focus on IVF that is healthier for you, easier on your body and better for your baby. It is our mission to protect the long-term health of women and babies; taking responsibility for the future, as well as the present.

Reduced risk of OHSS

Another known health risk of higher doses of stimulation hormones in women with a high egg reserve through conventional high-stimulation IVF is a potentially dangerous condition called Ovarian Hyperstimulation Syndrome (OHSS), with symptoms that can include:

  • Rapid weight gain
  • Persistent nausea
  • Vomiting
  • Shortness of breath
  • Tight or enlarged abdomen
  • Bloating

 

Mild OHSS can occur in up to 30% of women going through conventional high-stimulation IVF, but the severe form is rare. In contrast, Natural Modified IVF works with your natural menstrual cycle, greatly reduciesthe risk of OHSS.

If you are at high risk of developing an oestrogen-related cancer because of family history, or have endometriosis or other medical conditions (such as melanomas or clotting problems) that could be affected by ovarian stimulation drugs, Natural Modified IVF may be better suited to protect your health.

Improved quality eggs

Eggs that are naturally selected by the body can be of higher quality than those produced in a stimulated IVF cycle. Naturally selected eggs can potentially have fewer abnormalities, while embryos created in conventional IVF can have an increased proportion of chromosomal abnormalities.

Reduced long-term health complications for babies

A 2017 study found that there is a reduced risk of babies born through Natural Cycle IVF having a low birth weight and prematurity.

Better for implantation

Research has shown that high levels of stimulation can adversely impact embryo implantation.

By reducing stimulating drugs, the womb is more receptive as there is a healthier womb lining, and therefore more chance of the embryo successfully implanting, leading to a healthy pregnancy.

 

Your IVF treatment journey at CREATE

Previous step
Step 1:
Step 2:
Step 3:
Step 4:
Step 5:
Step 5:
Next step
  • Virtual Consultation

    The first step in your journey will be a Virtual Consultation with one of our highly experienced Fertility Consultants, which you can do via video or phone, from your own home.

  • Treatment Consultation

    2 weeks before the start of your period you will come in to meet with a fertility nurse who will talk you through your treatment plan and go through the consent forms with you.

     

  • Scans & Blood tests

    You will have 2 or 3 monitoring scans usually spaced days apart; each takes 20 minutes. The doctor may perform blood tests at these appointments.

     

  • Egg collection

    This procedure is performed in the theatre under sedation and takes around 45 minutes.

     

  • Embryo Transfer

    The embryo transfer is a quick and easy procedure which does not need sedation and feels similar to a smear test

  • Pregnancy test

    We will invite you back to the clinic for a pregnancy blood test and give you the test results by the end of the day.

 

What's the difference between conventional high stimulation IVF & Natural Modified IVF?

In conventional high-stimulation IVF drugs are given in the form of daily injections for up to 21-28 days before egg collection. In Natural Modified IVF, medication is given for just 3-4 days, therefore greatly reducing the overall number of injections and the duration of treatment. The below diagram shows the potential difference in injection times, medication dosage and treatment duration between Natural and conventional high stimulation IVF methods:

Natural Modified IVF & Conventional IVF overview

  Natural Modified
IVF
Conventional
IVF
Patient suitability • Older patients
• Lower ovarian reserve
• Want to reduce risks & side-effects
• Want less medication
Good ovarian reserve (under 35 years old)
Injection time 3-4 days 21-28
days
Medication dosage None -
Low
Medium -
High
Treatment duration Up to
2 weeks
Up to
4 weeks
Cycle control Works with a woman's natural menstrual cycle Shuts down natural menstrual cycle (downregulation)
Time between cycles No break needed 2-3 months break due to stimulation
Focus of treatment Quality of eggs & embryos Quantity of eggs & embryos
For women    
Reduced injections
Shorter treatment time
Greatly reduced side-effects
Reduced stress/emotional impact
Reduced risk of OHSS
Potentially for babies    
Reduced risk of low birth weights
Reduced risk of prematurity
Reduced risk of long-term health implications
 

Natural Modified IVF success rates

CREATE Fertility has the most experience and expertise in Natural Cycle IVF in the UK. We have pioneered new protocols and methods to advance this IVF treatment and to increase its success rates for all ages.

As these treatment are offered to women with low egg reserve the success rates can be lower per cycle but Cumulative success rate with 3 cycles of treatment can be significantly higher. This gives you the opportunity to try with your own eggs rather than having to use donor eggs.

Clinical pregnancies per embryo transferred | Natural Cycle IVF | Jan 18 - Dec 18 | CREATE St Paul's

 

Natural Modified IVF costs from £2,700*

Our treatment package includes:

-Treatment consultation
-Monitoring scans
-Egg collection
-Embryology
-Embryo transfer
-Early pregnancy scan

The cost of Natural Modified IVF will depend on your individual circumstances and your personalised treatment plan will be explained to you in more detail at your Initial Consultation.

We have various packages available to help patients with planning their treatment costs, if you wish to find out more about Natural Cycle IVF or our prices please give us a call.

Required additions: There are additional costs which cover medication, blood tests, sedation and HFEA fees that are not included in the price stated above. The ‘average’ total cost of a treatment cycle is £3,785 (this can vary based on individual patients requirements, an exact quote will be given at your consultation).

Your funding options

Cost is one of the biggest implications of private fertility treatment, we aim to make our treatments accessible for all so that's why we offer different funding options to help growing your family less stressful. To discuss funding options with one of our advisors contact us.

Payment plans available

  • 0% interest available over 12 months
  • Spread the cost of treatment with our affordable payment plans
  • 12 and 24 month plans available

3 cycle packages

  • 3 and 6 cycle packages
  • Better value for patients who require more than one cycle
  • Can offer better success rates in some patient circumstances
 

Our thoughts on Natural Modified IVF

Read the latest stories, advice and news from the CREATE Fertility blog.