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Scientific research

Scientific research

Our senior team works hard to remain at the forefront of the field, developing the latest advances in treatment.

We provide women-friendly treatment that delivers better health outcomes for mothers and babies. Our pioneering approach focuses on the quality of eggs, not the egg quantity. 

We provide women-friendly treatment that delivers better health outcomes for mothers and babies. Our pioneering approach focuses on the quality of eggs, not the egg quantity. 

Relevant medical research papers

Peer reviewed scientific papers which are available on Pub Med and via journal publishers

Natural IVF Research

Accumulation of embryos over 3 natural modified IVF (ICSI) cycles followed by transfer to improve the outcome of poor responders.

Datta AK, Campbell S, Felix N, Nargund G.

Facts Views Vis Obgyn. 2019 Mar;11(1):77-84.PMID: 31695860 [PubMed - indexed for MEDLINE]

Changes in practice make analysis of historical databases irrelevant for comparison between Natural and Stimulated IVF.

Nargund G, Campbell S.

Hum Reprod. 2017 Apr 1;32(4):963. doi: 10.1093/humrep/dex038.PMID: 28333224 [PubMed - indexed for MEDLINE]

Ovarian reserve may be compromised after adnexal surgery: Are we sufficiently fertility-focused in our surgical training?

Kalra GS, Campbell S, Nargund G.

Facts Views Vis Obgyn. 2016 Jun 27;8(2):104-108.PMID: 27909567 [PubMed - indexed for MEDLINE]

A successful pregnancy following 'double rescue' egg retrieval in a woman with Natural cycle IVF.

Nargund G, Chian RC, Campbell S.

Facts Views Vis Obgyn. 2014;6(2):96-8.PMID: 25009732 [PubMed - indexed for MEDLINE]

Natural/mild assisted reproductive technologies: reducing cost and increasing safety.

Nargund G.

Womens Health (Lond). 2009 Jul;5(4):359-60. doi: 10.2217/whe.09.32.PMID: 19586428 [PubMed - indexed for MEDLINE]

Towards a more physiological approach to IVF.

Nargund G, Frydman R.

Reprod Biomed Online. 2007 May;14(5):550-2.PMID: 17509190 [PubMed - indexed for MEDLINE]

Cumulative conception and live birth rates in natural (unstimulated) IVF cycles.

Nargund G, Waterstone J, Bland J, Philips Z, Parsons J, Campbell S.

Hum Reprod. 2001 Feb;16(2):259-62.PMID: 11157816 [PubMed - indexed for MEDLINE]

Current status of subfertility care: time to rationalize treatment options.

Nargund G.

Curr Opin Obstet Gynecol. 2000 Jun;12(3):199-200.PMID: 10873120 [PubMed - indexed for MEDLINE]

Mild IVF Research

Mild stimulation for in vitro fertilization.

Nargund G, Datta AK, Fauser BCJM.

Fertil Steril. 2017 Oct;108(4):558-567. doi: 10.1016/j.fertnstert.2017.08.022.PMID: 28965549 [PubMed - indexed for MEDLINE]

Mild approaches in assisted reproduction-better for the future?

Frydman R, Nargund G.

Fertil Steril. 2014 Dec;102(6):1540-1. doi: 10.1016/j.fertnstert.2014.10.018. Epub 2014 Nov 25.PMID: 25458619 [PubMed - indexed for MEDLINE]

Mild ovarian stimulation for IVF: 10 years later.

Fauser BC, Nargund G, Andersen AN, Norman R, Tarlatzis B, Boivin J, Ledger W.

Hum Reprod. 2010 Nov;25(11):2678-84. doi: 10.1093/humrep/deq247. Epub 2010 Sep 21.PMID: 20858698 [PubMed - indexed for MEDLINE]

Mild ovarian stimulation for IVF.

Verberg MF, Macklon NS, Nargund G, Frydman R, Devroey P, Broekmans FJ, Fauser BC.

Hum Reprod. 2010 Nov;25(11):2678-84. doi: 10.1093/humrep/deq247. Epub 2010 Sep 21.PMID: 19091755 [PubMed - indexed for MEDLINE]

Mild ovarian stimulation for IVF is the smartest way forward

Nargund G, Fauser BC.

Reproductive Biomedicine Online. 2020 May;22

Mild versus conventional ovarian stimulation for IVF in poor responders: a systematic review and meta-analysis

Datta AK, Maheshwari A, Felix N, Campbell S, Nargund G, .

Reproductive Biomedicine Online. 2020 March;13

Oocyte or embryo number needed to optimize live birth and cumulative live birth rates in mild stimulation IVF cycles

Nargund G, Fauser BC.

Reproductive Biomedicine Online. 2020 May;22

Mild versus conventional ovarian stimulation for IVF in poor responders: a systematic review and meta-analysis

Datta AK, Campbell S, Felix N, Singh J , Nargund G, .

Reproductive Biomedicine Online. 2021 February;22

Advanced Ultrasound Research

Giants in Obstetrics and Gynecology Series: a profile of Stuart Campbell, DSc, FRCPEd, FRCOG, FACOG

Roberto Romero, MD, DMedSci

American Journal of Obstetrics & Gynecology, VOLUME 223, ISSUE 2, P152-166, AUGUST 01, 2020

Absence of follicular phase defect in women with recurrent miscarriage.

Prakash A, Li TC, Laird S, Nargund G, Ledger WL.

Fertil Steril. 2006 Jun;85(6):1784-90. Epub 2006 Apr 27.PMID: 16643909 [PubMed - indexed for MEDLINE]

Evaluation of endometrial receptivity during in-vitro fertilization using three-dimensional power Doppler ultrasound.

Järvelä IY, Sladkevicius P, Kelly S, Ojha K, Campbell S, Nargund G.

Ultrasound Obstet Gynecol. 2005 Dec;26(7):765-9.PMID: 16270378 [PubMed - indexed for MEDLINE]

Comparison of follicular vascularization in normal versus polycystic ovaries during in vitro fertilization as measured using 3-dimensional power Doppler ultrasonography.

Järvelä IY, Sladkevicius P, Kelly S, Ojha K, Campbell S, Nargund G.

Fertil Steril. 2004 Nov;82(5):1358-63.PMID: 15533360 [PubMed - indexed for MEDLINE]

Quantification of ovarian power Doppler signal with three-dimensional ultrasonography to predict response during in vitro fertilization.

Järvelä IY, Sladkevicius P, Kelly S, Ojha K, Campbell S, Nargund G.

Obstet Gynecol. 2003 Oct;102(4):816-22.PMID: 14551013 [PubMed - indexed for MEDLINE]

Effect of pituitary down-regulation on the ovary before in vitro fertilization as measured using three-dimensional power Doppler ultrasound.

Järvelä IY, Sladkevicius P, Kelly S, Ojha K, Campbell S, Nargund G.

Fertil Steril. 2003 May;79(5):1129-35.PMID: 12738507 [PubMed - indexed for MEDLINE]

Side of ovulation and its effects on uterine and ovarian stromal blood flow and reproductive hormones.

Ojha K, Sladkevicius P, Scaramuzzi R, Collier T, Campbell S, Nargund G.

Fertil Steril. 2003 Feb;79(2):367-73.PMID: 12568847 [PubMed - indexed for MEDLINE]

Characterization of normal and polycystic ovaries using three-dimensional power Doppler ultrasonography.

Ojha K, SladkevJärvelä IY, Mason HD, Sladkevicius P, Kelly S, Ojha K, Campbell S, Nargund G.

J Assist Reprod Genet. 2002 Dec;19(12):582-90.PMID: 12503891 [PubMed - indexed for MEDLINE]

Intraobserver and interobserver variability of ovarian volume, gray-scale and color flow indices obtained using transvaginal three-dimensional power Doppler ultrasonography.

Järvelä IY, Sladkevicius P, Tekay AH, Campbell S, Nargund G.

Ultrasound Obstet Gynecol. 2003 Mar;21(3):277-82.PMID: 12666224 [PubMed - indexed for MEDLINE]

Is aspirin all it is cracked up to be-reproducibility of transvaginal color Doppler ultrasonography for ovarian and uterine vessels?

Sladkevicius P, Nargund G, Campbell S.

Fertil Steril. 2000 May;73(5):1069-71. No abstract available. Erratum in: Fertil Steril 2000 Jul;74(1):190. Sladkevicius DP [corrected to Sladkevicius P]. PMID: 10785243 [PubMed - indexed for MEDLINE]

Advanced ultrasound technology in the management of infertility.

Nargund G.

J Indian Med Assoc. 1999 Feb;97(2):62-4. Review. No abstract available. PMID: 10549197 [PubMed - indexed for MEDLINE]

In Vitro Maturation

In vitro maturation of human immature oocytes for fertility preservation.

Chian RC, Uzelac PS, Nargund G.

Fertil Steril. 2013 Apr;99(5):1173-81.PMID: 23433515 [PubMed - indexed for MEDLINE]

Affordable IVF

The (t)WE lab Simplified IVF Procedure: First Births after freezing/thawing.

Ombelet W, Van Blerkom J, Klerkx E, Janssen M, Dhont N, Mestdagh G, Nargund G, Campo R.

Facts Views Vis Obgyn. 2014;6(1):45-9.PMID: 25009725 [PubMed - indexed for MEDLINE]

First births with a simplified culture system for clinical IVF and embryo transfer.

Van Blerkom J, Ombelet W, Klerkx E, Janssen M, Dhont N, Mestdagh G, Nargund G, Campo R.

Facts Views Vis Obgyn. 2014 Mar;28(3):310-20.PMID: 24456702 [PubMed - indexed for MEDLINE]

Fertility Education & Funding

Why Fertility Education is needed in schools.

Nargund G.

Facts Views Vis Obgyn. 2015;7(3):189-91.PMID: 26977269 [PubMed - indexed for MEDLINE]

Egg Freezing

Helping Woman with their Fertility should be part of the Agenda for Gender Equality.

Nargund G.

Facts Views Vis Obgyn. 2014 Mar;6(1):50.PMID: 25009726 [PubMed - indexed for MEDLINE]

General IVF Research

A prospective randomized study comparing needles of different diameters for transvaginal ultrasound-directed follicle aspiration.

Awonuga A, Waterstone J, Oyesanya O, Curson R, Nargund G, Parsons J.

Fertil Steril. 1996 Jan;65(1):109-13.

Comparison of endocrinological and clinical profiles and outcome of IVF cycles in patients with one ovary and two ovaries.

Nargund G, Bromhan D.

J Assist Reprod Genet. 1995 Aug;12(7):458-60. No abstract available. PMID: 8574076 [PubMed - indexed for MEDLINE]

Infected endometriotic cysts secondary to oocyte aspiration for in-vitro fertilization.

Nargund G, Parsons J.

Hum Reprod. 1995 Jun;10(6):1555. No abstract available. PMID: 7593536 [PubMed - indexed for MEDLINE]

Course and outcome of IVF pregnancies and spontaneous conceptions within an IVF setting

Harrison RF, Hennelly B, Woods T, Lowry K, Kondaveeti U, Barry-Kinsella C, Nargund G.

Eur J Obstet Gynecol Reprod Biol. 1995 Apr;59(2):175-82.PMID: 7657012 [PubMed - indexed for MEDLINE]

Case report: benign neural tumour of small bowel presenting as a pelvic mass.

Nargund G.

Clin Exp Obstet Gynecol. 1995;22(3):202-3. No abstract available. PMID: 7554257 [PubMed - indexed for MEDLINE]

An Irish out-patient based in-vitro fertilisation service.

Harrison RF, Barry-Kinsella C, Drudy L, Gordon A, Hannon K, Hennelly B, Keogh I, Kondaveeti U, Nargund G, Verso J.

Ir Med J. 1992 Jun;85(2):63-5.PMID: 1628945 [PubMed - indexed for MEDLINE]

Selection of fertilization strategies for different sperm parameters in vitro fertilization

Lingling Qiu, Jinxiang Wu, Jing Chen, Hui Cao, Jingjing Cai, Xiaolan Huang, Ruiyun Wu, Yuanzhi Xie, Renata Finelli, Yali He, Suzhen Huang, Zhengyao Wang.

Ann Transl Med 2022;10(18):996

 

Male Factor Infertility

Traditional, Complementary and Alternative Medicines in the
Treatment of Ejaculatory Disorders: A Systematic Review

Kristian Leisegang, Chinyerum Sylvia Opuwari, Faith Moichela and Renata Finelli.

Medicina 2023, 59(9), 1607

Global Analysis in Nonobstructive Azoospermic Testis Identifies miRNAs Critical to Spermatogenesis

Fahimeh Piryaei, Hossein Mozdarani, Mohammad Ali Sadighi Gilani, Singh Rajender, Renata Finelli, Mahsa Darestanifarahani, Abdolazim Sarli, Poonam Mehta and Ashok Agarwal.

Volume 2023 | Article ID 2074931 |

Eurycoma longifolia (Jack) Improves Serum Total
Testosterone in Men: A Systematic Review and Meta-Analysis
of Clinical Trials

Kristian Leisegang 1, Renata Finelli, Suresh C. Sikka and Manesh Kumar Panner Selvam.

Medicina 2022, 58, 1047

Alternative medicine and herbal remedies in the treatment of erectile dysfunction: A systematic review

Kristian Leisegang a and Renata Finelli.

ARAB JOURNAL OF UROLOGY 2021, VOL. 19, NO. 3, 323–339

Polymorphic Rearrangements of Human Chromosome 9 and
Male Infertility: New Evidence and Impact on Spermatogenesis

Filomena Mottola, Marianna Santonastaso, Valentina Ronga, Renata Finelli and Lucia Rocco.

Biomolecules 2023, 13, 729

The Impact of COVID-19 Vaccines on Male Semen Parameters: A Retrospective Cohort Study

Kristian Leisegang, Renata Finelli, Lionel Moungala, Faith Moichela, Keenau Pearce, Ranjith Ramasamy and Ralf Henkel.

Volume 2023 | Article ID 7826568

 

 

 

Other Research

Gene-specific chromatin damage in human spermatozoa can be blocked by antioxidants that target mitochondria.

Lamond S, Watkinson M, Rutherford T, Laing K, Whiting A, Smallwood A, Nargund G, Campbell S, Banerjee S.

Reprod Biomed Online. 2003 Oct-Nov;7(4):407-18.PMID: 14656402 [PubMed - indexed for MEDLINE]

Igf2/H19 imprinting control region (ICR): an insulator or a position-dependent silencer?

Banerjee S, Smallwood A, Lamond S, Campbell S, Nargund G.

ScientificWorldJournal. 2001 Jun 5;1:218-24. Review.PMID: 12806090 [PubMed - indexed for MEDLINE]

Placental morphogenesis in pregnancies with Down’s syndrome might provide a clue to pre-eclampsia.

Banerjee S, Smallwood A, Nargund G, Campbell S.

Placenta. 2002 Feb-Mar;23(2-3):172-4. Review.PMID: 11945083 [PubMed - indexed for MEDLINE]

Successful planned delay of ovulation for one week with indomethacin.

Nargund G, Wei CC.

J Assist Reprod Genet. 1996 Sep;13(8):683-4. No abstract available. PMID: 8897131 [PubMed - indexed for MEDLINE]

The Mechanisms and Management of Age-Related Oxidative Stress in Male Hypogonadism Associated with Non-communicable Chronic Disease

Kristian Leisegang, Shubhadeep Roychoudhury, Petr Slama and Renata Finelli.

Antioxidants 2021, 10, 1834.

The Effect of Aqueous Lessertia frutescens Extract on TM3 Leydig Cells Exposed to TNF-α in vitro

Kristian Leisegang, Renata Finelli2, Ralf Henkel, Cătălina Zenoaga-Barbăroșie

Front. Biosci. (Landmark Ed) 2023, 28(9), 213;

 

 

In the media

Read the latest news coverage featuring CREATE Fertility or our Medical Director, Professor Geeta Nargund.