What is PGS?

PGS is a technique used to assess embryos for chromosomal abnormalities. It involves the removal of one or more cells from embryos before they are transferred.

This is followed by testing of the cells to find out the number of chromosomes, using either NGS or array-CGH methods. If the cells are found to have an abnormal chromosome number, then the embryo is less likely to implant. In this way embryos can be screened in order to select the most viable embryos for embryo transfer.  

Interested in PGS?

If you would like to find out more about PGS then please contact our IVF specialists.

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Who is PGS suitable for?

PGS can be used by any person/couple undergoing an IVF cycle, but is most suitable for older women who are more likely to have eggs with the wrong number of chromosomes. Abnormal chromosomes are thought to be the main reason why older women have difficulties conceiving and are more likely to have a miscarriage or a baby with Down’s Syndrome.

You may also be recommend PGS if:

  • you have a family history of chromosome problems
  • your sperm is at risk of carrying abnormal chromosomes
  • if you’ve had several miscarriages or failed IVF attempts without explanation

Advantages of PGS

Improves IVF success rates
Improves IVF success rates
Improves IVF success rates

Recent research has suggested that IVF success rates might be improved if embryos are screened for chromosome abnormalities with embryos that have the correct number of chromosomes given priority for transfer to the womb.

Accurate assessment of embryos
Accurate assessment of embryos
Accurate assessment of embryos

Data suggests that NGS results are correct over 95% of the time.

Down Syndrome
It can be used to diagnose Down Syndrome:
It can be used to diagnose Down Syndrome:

In PGS the number of chromosomes is examined and likely cases of Down Syndrome can be identified.

Reduce miscarriage
It can reduce miscarriage
It can reduce miscarriage

PGS is used to identify chromosomally normal embryos. These are more likely to be healthy, and are therefore more likely to implant successfully.

How safe is PGS for embryos?

Performing PGS on embryos at blastocyst stage has little or no effect on the successful development of the embryo. This is because an embryo developed to this stage has many more cells, which can be extracted without affecting an embryo’s potential for pregnancy.

The cells which are extracted during PGS are called trophectoderm cells, which will go on to form the placenta.

 

pre-implantation genetic screening

How much does PGS cost?

Out cutting edge PGS with Next Generation Sequencing can be bought as part of a 3 Cycle IVF Package or can be added to a single cycle treatment.

  • PGS additional service £1,950
  • Part of a 3 Cycle Natural/Modified IVF package Save 10%
  • Part of a 3 Cycle Mild IVF package Save 23%

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